PharmGKB: A Resource to Link Genotype and Phenotype in Pharmacogenetics
نویسندگان
چکیده
The PharmGKB (http://www.pharmgkb.org/) is a pharmacogenetics and pharmacogenomics knowledge base built to support the representation, storage, analysis and dissemination of genotype and phenotype data. We have collected genetic sequence data from research centers in which polymorphic variations in genes of pharmacogenetic interest have been characterized in particular populations. PharmGKB also contains phenotype data sets that are linked to particular genotypes as well as information about key gene-drug interactions of relevance to pharmacogenetics obtained by curating the literature. PharmGKB integrates these data with relevant information from other databases and provides browsing and analytical functions to help scientists discover connections between genetic variations and alterations in drug effects and related phenotypes. Our objective is to catalyze research in the pharmacogenetics scientific community, and to discover the genetic basis for variations in the response to drugs.
منابع مشابه
Ontology Development for a Pharmacogenetics Knowledge Base
Research directed toward discovering how genetic factors influence a patient's response to drugs requires coordination of data produced from laboratory experiments, computational methods, and clinical studies. A public repository of pharmacogenetic data should accelerate progress in the field of pharmacogenetics by organizing and disseminating public datasets. We are developing a pharmacogeneti...
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Research directed toward discovering how genetic factors influence a patient’s response to drugs requires coordination of data produced from laboratory experiments, computational methods, and clinical studies. A public respository of pharmacogenetic data to which investigators from different centers can contribute will facilitate hypothesis generation for further research. We are developing a p...
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The Pharmacogenetics Knowledge Base (PharmGKB; http://www.pharmgkb.org/) contains genomic, phenotype and clinical information collected from ongoing pharmacogenetic studies. Tools to browse, query, download, submit, edit and process the information are available to registered research network members. A subset of the tools is publicly available. PharmGKB currently contains over 150 genes under ...
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